Complete remission of critical neurohistiocytosis by vemurafenib

Complete remission of critical neurohistiocytosis by vemurafenib

OBJECTIVE To describe a patient with life-threatening brainstem neurohistiocytosis who recovered completely upon targeted treatment with the V600E mutation-specific BRAF inhibitor vemurafenib. METHODS We report clinical, histiologic, genetic, and sequential imaging findings, including fluorodeoxyglucose (FDG)-PET, over a follow-up period of 11 months. RESULTS The patient presented with cent...

Low-dose vemurafenib induces complete remission in a case of hairy-cell leukemia with a V600E mutation.

Hairy-cell leukemia (HCL) is a lymphoproliferative disorder characterized by the presence of CD103-positive circulating B cells, pancytopenia and splenomegaly. HCL cases were recently shown to harbor a mutation at codon 600 of BRAF (V600E), suggesting that this genetic event represents a key driver of the disease. Recently, Dietrich et al. reported a case of refractory HCL treated with escalati...

first complete remission versus other- than- first complete remission in acute myelogenous leukemia with allogeneic hematopoietic stem cell transplantation

introduction: the traditional goal of the treatment of acute myelogenous leukemia is to produce and maintain a complete remission (cr).the difference in survival time was entirely attributable to the duration of time spent in cr .in this study, the outcome of aml patients with allogeneic hsct in cr1 versus other than cr1 was compared. patients and methods: since march 1991 until november 2008, ...

Complete remission in idiopathic membranous glomerulonephritis.

a critical analysis of ideology in discourse: the case of “the chrysanthemums” by john steinbeck تحلیل انتقادی ایدئولوژی در گفتمان: بررسی ’ گلهای داوودی’ اثر جان اشتاینبک

چکیده امروزه‚ اعتقاد بر این مطلب که زبان تنها ابزاری جهت برقراری ارتباط نبوده‚ بلکه وسیله ای در جهت شکل گیری هویت‚ ارزش ها‚ وایدئولوژی های اعضای جامعه می باشد به طور گسترده ای فراگیر شده است. بنابر این‚ گفتمان ها بی تاثیر از ایدئولوژی پدید آورندگان نبوده و متعاقبا بر درک خوانندگان یا شنوندگان از حقیقت تاثیرگذارند. فیرکلاف (2003) بر این باور است که گفتمان ها به واسطه ایدئولوژی غالبی که در خود د...